5-Amino-1MQ

5-Amino-1MQ has been examined in laboratory research studies as an inhibitor of NNMT, an enzyme associated with cellular metabolic pathways. These areas of investigation are of particular relevance:

• NNMT Interaction. 5-Amino-1MQ may inhibit NNMT activity with possible effects on NAD+ and S-adenosylmethionine (SAM) dynamics in experimental models.

• Adipocyte Biology. Research has explored the compound’s role in adipocyte systems, including investigations into lipid accumulation patterns and related metabolic processes.

• Mitochondrial Pathways. Preliminary studies suggest potential associations between 5-Amino-1MQ and mitochondrial outcomes, including investigations of biogenesis and cellular energy-related mechanisms.

• Metabolic Pathways. Studied for its potential to interact with NNMT and influence cellular metabolism in laboratory settings.

• Adipose Tissue Function. 5-Amino-1MQ has been investigated in relation to adipocyte metabolism, particularly its potential effects on lipid accumulation patterns.

• NAD+ Dynamics. In research models, scientists have examined this compound for associations with NAD+ availability and cellular energetics.

• Mitochondrial Function. Early studies have evaluated links between 5-Amino-1MQ and mitochondrial biogenesis and function.

• Methylation Support. The compound has been considered in studies of SAM availability and methylation-dependent cellular mechanisms.

5-Amino-1MQ has been examined in laboratory studies as a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Its structure has made it a subject of interest for investigating NNMT activity and related cellular pathways. 

Current work remains focused on preclinical and laboratory models, where ongoing studies continually explore its mechanisms and potential research applications.

1. Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571.

2. Kannt A, Pfenninger A, Teichert L, Tönjes A, Dietrich A, Schön MR, Klöting N, Blüher M. Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia. 2015 Apr;58(4):799-808. doi: 10.1007/s00125-014-3490-7. Epub 2015 Jan 18. PMID: 25596852; PMCID: PMC4351435.

3. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. PMID: 24717514; PMCID: PMC4107212.

4. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013 May;9(5):300-6. doi: 10.1038/nchembio.1204. Epub 2013 Mar 3. PMID: 23455543; PMCID: PMC3631284.

5. Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375.