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PTD-DBM
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Product description
PTD-DBM (Protein Transduction Domain-fused Dishevelled Binding Motif) is a synthetic peptide designed to target the CXXC5-Dishevelled protein interaction involved in hair follicle regeneration and wound healing pathways. Research suggests this engineered peptide may competitively interfere with CXXC5 binding to Dishevelled protein, potentially activating the Wnt/β-catenin signaling pathway critical for hair growth. The peptide structure combines a cell-penetrating arginine-rich domain, glycine linker, and Dishevelled-binding sequence that may collectively enhance cellular uptake and biological activity.Studies have primarily investigated PTD-DBM's potential applications in androgenetic alopecia, wound-induced hair neogenesis (WIHN), and cutaneous wound healing, with research indicating possible synergistic effects when combined with valproic acid (VPA) or other peptides like GHK-Cu. PTD-DBM is supplied as a white lyophilized powder and requires reconstitution with bacteriostatic water prior to experimental use.
This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
- Characteristics
- How is PTD-DBM Used in Research?
- Areas of Study
- Summary
- References
- Certificate of Analysis (COA)
- Resource
Table of Contents
- Characteristics
- How is PTD-DBM Used in Research?
- Areas of Study
- Summary
- References
- Certificate of Analysis (COA)
- Resource
Characteristics
| NAME | ROLE |
|---|---|
Molecular Formula | C₁₂₄H₂₂₅N₆₁O₂₈S₂ |
CAS Number | 120287-85-6 or 1609454-11-6 |
Molar Mass | 3082.62 g/mol |
Amino Acid Sequence | Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys |
Synonyms | Protein Transduction Domain-fused Dishevelled Binding Motif, Protein transduction domain (PTD)-Dvl-binding motif (DBM), Hair growth peptide, Follicle regeneration peptide |
Solubility | Water-soluble |
Organoleptic Profile | White to off-white powder |
Composition | Lyophilized powder - requires reconstitution |
How is PTD-DBM Used in Research?
PTD-DBM's mechanism of action research suggests it may primarily function as a peptide inhibitor of the CXXC5-Dishevelled protein interaction, potentially activating the Wnt/β-catenin signaling pathway. Studies indicate the peptide may demonstrate enhanced hair follicle regeneration properties through multiple potential pathways:
The primary mechanism research suggests may involve the competitive binding to the Dishevelled (Dvl) protein, potentially preventing CXXC5 from inhibiting the Wnt/β-catenin pathway. This interaction may lead to enhanced signaling for hair follicle development and regeneration through both direct and indirect cellular pathways.
Additionally, studies indicate PTD-DBM may have effects on wound-induced hair neogenesis (WIHN) and tissue regeneration. Research suggests it may stimulate stem cells in hair follicles and possibly enhance keratinocyte proliferation, potentially contributing to improved follicle cycling and hair growth phases.
The peptide's protein transduction domain (PTD) structure, consisting of eight arginine residues, may allow for enhanced cellular penetration, possibly leading to more consistent therapeutic effects when applied topically to affected areas.
Research also suggests potential synergistic effects when combined with compounds like valproic acid (VPA), which may further activate the Wnt/β-catenin pathway through GSK3β inhibition.
Areas of Study
Hair Follicle Regeneration: Research suggests it may have potential effects on new hair follicle formation and may prevent follicle miniaturization associated with androgenetic alopecia.
Wound Healing: Studies indicate it may improve cutaneous wound healing and may offer potential benefits for tissue regeneration and collagen synthesis.
Extended Effects: Research suggests hair growth may be maintained even after treatment cessation, potentially indicating sustained follicle activation.
Stem Cell Activation: Studies suggest it may have effects on follicle stem cell populations, potentially contributing to enhanced anagen phase duration.
Combination Potential: Research indicates there may be possible synergistic effects when combined with other therapeutic agents like valproic acid or microneedling procedures.
Summary
PTD-DBM may represent an advancement in peptide-based hair regeneration research, particularly in the field of androgenetic alopecia management. Its unique structure targeting the CXXC5-Dvl interaction may provide a novel approach to activating hair growth pathways while potentially maintaining beneficial effects even after treatment discontinuation. Current research suggests there may be promising applications in both hair loss prevention and active follicle regeneration, with ongoing studies exploring additional therapeutic potential in wound healing and tissue repair.
References
Resource
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